PP-046 - Relative amount of mitochondria DNA (MTDNA) in euploid and aneuploid blastocysts

Cell-free fetal DNA in amniotic fluid: unique fragmentation signatures in euploid and aneuploid fetuses.

BACKGROUND Circulating cell-free fetal deoxyribonucleic acids (cffDNA) are novel biomarkers with many clinical applications. Amniotic fluid (AF) is a rich source of cffDNA. We investigated the biophysical characteristics of cffDNA in AF, hypothesizing that they would differ from cffDNA in maternal plasma. METHODS We obtained 10 mL of fresh AF supernatant from women carrying euploid fetuses (n...

Extracellular chromosome 21-derived microRNAs in euploid & aneuploid pregnancies

BACKGROUND & OBJECTIVES Trisomy 21 is the most common chromosomal aneuploidy in live born infants. Recently, the over expression of chromosome 21-derived microRNAs (miR-99a, let-7c, miR-125b-2, miR-155 and miR-802) in human fetal hippocampus and heart samples from individuals with Down syndrome was observed. Therefore, concentrations and expression profile of extracellular chromosome 21-derived...

comparison of the amount of debris extruded apically in two rotary techniques: flexmaster and m2

چکیده ندارد.

Altered Levels of Mitochondrial DNA Are Associated with Female Age, Aneuploidy, and Provide an Independent Measure of Embryonic Implantation Potential

Mitochondria play a vital role in embryo development. They are the principal site of energy production and have various other critical cellular functions. Despite the importance of this organelle, little is known about the extent of variation in mitochondrial DNA (mtDNA) between individual human embryos prior to implantation. This study investigated the biological and clinical relevance of the ...

Effect of Culture System on Developmental Competence, Cryosurviva and DNA-Fragmentation of In Vitro Bovine Blastocysts